[BostonCard]

absolutely not a representative sample, but I don't care if the true prevalence is as low as 1%, that would be unacceptably high IMO.  I also don't think this is "OT"  :) this is critical to college football in general and to the health of our student athletes specifically!

Yes, exactly.  While not a representative sample by any means, the denominator of all people who have played NFL football is not that large.  That 100+ NFL players all had evidence of CTE in their brains means that even if zero of the former NFL players who did not donate their brains would have had evidence of CTE, that's still a substantial numerator.

Of course pathological evidence of CTE doesn't necessarily mean it was symptomatic/clinically significant, though, as noted most of the players who donated had some sort of symptoms (though those may or may not have had anything to do with CTE).

BC

[BostonCard]

absolutely not a representative sample, but I don't care if the true prevalence is as low as 1%, that would be unacceptably high IMO.  I also don't think this is "OT"  :) this is critical to college football in general and to the health of our student athletes specifically!

Yes, exactly.  While not a representative sample by any means, the denominator of all people who have played NFL football is not that large.  That 100+ NFL players all had evidence of CTE in their brains means that even if zero of the former NFL players who did not donate their brains would have had evidence of CTE, that's still a substantial numerator.

Of course pathological evidence of CTE doesn't necessarily mean it was symptomatic/clinically significant, though, as noted most of the players who donated had some sort of symptoms (though those may or may not have had anything to do with CTE).

BC