[gocard14]

[quote author=dabigv link=topic=17092.msg196104#msg196104 date=1501191073]
At this point, I think epidemiologic studies will be far more valuable than these sorts of pathologic studies we always read about.

What meaning do these pathologic changes have clinically? That's still not clear.

That's something I've been curious about, when they've shown pictures of the autopsied brains, they're very clearly different from healthy brains, including in size. Why isn't that visible on an MRI or some other scan? Is something about those pictures misleading?
[/quote]

Size and overall atrophy of the brain is clearly visible on CT, but is a normal finding with aging or other forms of neurocognitive decline. The extra space inside the skull from an atrophied brain is one reason that the elderly have much higher rates of intracranial bleeds from minor trauma as the brain has more freedom of motion to shear attached vessels.

[gocard14]

[quote author=dabigv link=topic=17092.msg196104#msg196104 date=1501191073]
At this point, I think epidemiologic studies will be far more valuable than these sorts of pathologic studies we always read about.

What meaning do these pathologic changes have clinically? That's still not clear.

That's something I've been curious about, when they've shown pictures of the autopsied brains, they're very clearly different from healthy brains, including in size. Why isn't that visible on an MRI or some other scan? Is something about those pictures misleading?
[/quote]

Size and overall atrophy of the brain is clearly visible on CT, but is a normal finding with aging or other forms of neurocognitive decline. The extra space inside the skull from an atrophied brain is one reason that the elderly have much higher rates of intracranial bleeds from minor trauma as the brain has more freedom of motion to shear attached vessels.