[dabigv13]

A great post BC.

One thing that concerns me about the major early vaccine candidates is they are all new approaches (and of course they are the early ones partly because more traditional approaches historically have taken longer). No mRNA vaccines have ever been through large human trials. Adenovirus vaccines have been around longer and tested in some trials, but none have passed FDA or European approval (the Chinese have approved some) AFAIK. I'm certainly no specialist in vaccines, but just that on it's face gives me a higher level of skepticism about both safety and efficacy.

Some articles that I've found infromative-

https://cen.acs.org/pharmaceuticals/vacc...-19/98/i19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906799/

[dabigv13]

A great post BC.

One thing that concerns me about the major early vaccine candidates is they are all new approaches (and of course they are the early ones partly because more traditional approaches historically have taken longer). No mRNA vaccines have ever been through large human trials. Adenovirus vaccines have been around longer and tested in some trials, but none have passed FDA or European approval (the Chinese have approved some) AFAIK. I'm certainly no specialist in vaccines, but just that on it's face gives me a higher level of skepticism about both safety and efficacy.

Some articles that I've found infromative-

https://cen.acs.org/pharmaceuticals/vacc...-19/98/i19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906799/