12-08-2020, 12:40 PM
I believe they are planning another trial (or at least they were):
https://www.reuters.com/article/us-healt...SKBN28620H
The question is whether what they have now is sufficient to get an EUA. I would guess so, based on the stated goalposts (>50% efficacy and lower bound of the CI > 30%), which they meet. Given that it offers the best chance to mass vaccinate quickly, I think it is probably worth moving forward with it. But I would like to see a three arm trial of half-dose versus full-dose versus placebo (or at least the half-dose versus placebo) to verify the ~90%.
https://www.wsj.com/articles/astrazeneca...1607443250
AZ/Oxford will indeed submit the data.
BC
https://www.reuters.com/article/us-healt...SKBN28620H
The question is whether what they have now is sufficient to get an EUA. I would guess so, based on the stated goalposts (>50% efficacy and lower bound of the CI > 30%), which they meet. Given that it offers the best chance to mass vaccinate quickly, I think it is probably worth moving forward with it. But I would like to see a three arm trial of half-dose versus full-dose versus placebo (or at least the half-dose versus placebo) to verify the ~90%.
https://www.wsj.com/articles/astrazeneca...1607443250
AZ/Oxford will indeed submit the data.
BC