[BostonCard]

A single dose arm would have been interesting. Seems highly effective after one dose. Given the supply constraints, a highly effective single dose would be much better at saving lives/ending pandemic even if efficacy is more like 80-85% compared to 90-95%.

Doubt Pfizer would go along with that sort of study now that they are on brink of approval. And very unlikely FDA would approve that dose regimen without a study. Will have to wait for retrospective data on people who only got one dose for whatever reason to tease out more fully.

See this tweet thread, arguing more or less the same:

[tweet]https://twitter.com/zeynep/status/1337047714341785605?s=20[/tweet]

Interestingly Scott Gottlieb is disagreeing with the government's distribution plans.



I agree with Gottlieb here.  Get the first dose into as many arms as possible as quickly as possible, and worry about the second dose as it becomes available.

BC

[BostonCard]

A single dose arm would have been interesting. Seems highly effective after one dose. Given the supply constraints, a highly effective single dose would be much better at saving lives/ending pandemic even if efficacy is more like 80-85% compared to 90-95%.

Doubt Pfizer would go along with that sort of study now that they are on brink of approval. And very unlikely FDA would approve that dose regimen without a study. Will have to wait for retrospective data on people who only got one dose for whatever reason to tease out more fully.

See this tweet thread, arguing more or less the same:

[tweet]https://twitter.com/zeynep/status/1337047714341785605?s=20[/tweet]

Interestingly Scott Gottlieb is disagreeing with the government's distribution plans.



I agree with Gottlieb here.  Get the first dose into as many arms as possible as quickly as possible, and worry about the second dose as it becomes available.

BC