Some early monoclonal antibody results - Printable Version
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RE: Some early monoclonal antibody results - dabigv13 - 12-18-2020
To run infusion clinics for these mAbs you need space and nurses. Hard to come by right now.
RE: Some early monoclonal antibody results - BostonCard - 12-18-2020
Here's the New England Journal article:
https://www.nejm.org/doi/full/10.1056/NEJMoa2035002?query=RP
Quote:In the overall trial population, 6% of the patients in the placebo group and 3% of the patients in the combined REGN-COV2 dose groups reported at least one medically attended visit; among patients who were serum antibody–negative at baseline, the corresponding percentages were 15% and 6% (difference, −9 percentage points; 95% CI, −29 to 11).
The paper only reports "medically attended visit" as an endpoint, and I would guess that hospitalization is a small subset of that. With a 3% absolute risk difference, you would have to treat 30 patients to prevent one "medically attended visit".
BC
RE: Some early monoclonal antibody results - M T - 12-18-2020
Absolutely yes. This is what I was trying to get for my relative who got the false positive.
The sluggishness of the facility ("No, I can't pass a message to the doctor. No, the administrator doesn't work on the weekends.") was a big impediment for this. The 3-day delay in getting the PCR test back was almost too long for the "within 3 days of first symptoms" for the drug.
For my other relative who actually did get COVID, the 3 days to get the test results back made it already too late because she had symptoms before the test.
RE: Some early monoclonal antibody results - Goose - 12-20-2020
https://www.nbcnews.com/health/health-news/godsend-or-not-worth-effort-monoclonal-antibodies-divide-overwhelmed-covid-n1251684
Covers the pros and cons. It will be interesting to see the clinical trial results as they become available.