Higher death rates in patients treated with HCQ - Printable Version
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Higher death rates in patients treated with HCQ - akiddoc - 04-21-2020
https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1
Retrospective study from the VA.
RE: Higher death rates in patients treated with HCQ - BostonCard - 04-21-2020
I referred to this study here: https://thecardboard.org/board/showthread.php?tid=19212&pid=277823#pid277823
I think as with all retrospective studies, there are some potential problems with it (confounding by indication) even though they attempt to control for it. As I said in the post, I'll wait for the results of randomized, placebo controlled studies, but presumably if HCQ were a "game-changer" it would be obvious even in a retrospective trial like this. So, I will wait for the randomized placebo controlled trial to make up my mind.
BC
RE: Higher death rates in patients treated with HCQ - akiddoc - 04-21-2020
So many threads that I did not see your post.
Not a perfect study of course but I think the with this study, the French experience and the Brazilian study, I'm not very hopeful that very sick individuals will see a benefit.
RE: Higher death rates in patients treated with HCQ - OutsiderFan - 04-22-2020
(04-21-2020, 11:13 PM)akiddoc Wrote: So many threads that I did not see your post.
Not a perfect study of course but I think the with this study, the French experience and the Brazilian study, I'm not very hopeful that very sick individuals will see a benefit.
I've seen some speculation that Zinc should be used in combo with HCQ because Zinc helps open pathways for HCQ to get into virus cells. I have no idea if this is true or not.
RE: Higher death rates in patients treated with HCQ - BostonCard - 04-22-2020
High doses of zinc can cause anosmia, which has been documented as a symptom of COVID-19. So be careful.
Secondly there are no viral cells. There are viral particles and virus-infected (human) cells.
BC
RE: Higher death rates in patients treated with HCQ - oldalum - 04-22-2020
(04-22-2020, 07:16 AM)OutsiderFan Wrote: I've seen some speculation that Zinc should be used in combo with HCQ because Zinc helps open pathways for HCQ to get into virus cells.Don't know anything about that, although ACE2 is a zinc-containing metalloenzyme. I only remember seeing that increased intracellular levels of zinc inhibits RNA-dependent RNA polymerase (i.e., viral genome replication).
RE: Higher death rates in patients treated with HCQ - ChicagoCard - 04-22-2020
(04-22-2020, 09:44 AM)BostonCard Wrote: High doses of zinc can cause anosmia, which has been documented as a symptom of COVID-19. So be careful.
So well beyond the 20mg in my daily men's vitamin?
RE: Higher death rates in patients treated with HCQ - BostonCard - 04-22-2020
Usually seen with zinc lozenges, rather than zinc as part of a multi-vitamin.
BC