Chloroquine/hydroxychloroquine and QT - Printable Version
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Chloroquine/hydroxychloroquine and QT - BostonCard - 05-02-2020
One of the known side effects of hydroxychloroquine and chloroquine is a prolongation of the QT interval on ECG. This prolongation puts people at risk with a cardiac arrhythmia known as torsades des pointes (or TdP), which can be fatal. Now, we are seeing evidence that COVID-19 patients on chloroquine and hydroxychloroquine have developed dangerous QT prolongations.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2765633?guestAccessKey=fd68e676-cef4-47e6-8415-502c6da16fca&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamacardiology&utm_content=olf&utm_term=050120
and
https://jamanetwork.com/journals/jamacardiology/fullarticle/2765631?guestAccessKey=c9a55505-f2d5-4ef1-893e-1bcb3ffa3b02&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamacardiology&utm_content=olf&utm_term=050120
BC
RE: Chloroquine/hydroxychloroquine and QT - akiddoc - 05-02-2020
Giving two QT prolonging agents together is a recipe for killing people. Remember Cisapride? It was removed from the market because physicians kept prescribing it together with Erythromycin or Azithromycin, and people died.
RE: Chloroquine/hydroxychloroquine and QT - BostonCard - 05-03-2020
From Mass General Hospital:
https://advances.massgeneral.org/research-and-innovation/article.aspx?id=1187&utm_medium=email&utm_source=marketo-providers&utm_campaign=FY20-pulmonaryadvances-02may2020&mkt_tok=eyJpIjoiWm1SbVltWTJZMlU0WkRrdyIsInQiOiJQR3VPU1U5QWZrbnkrNk10emtBeDhmTzdcL1FRVlwvMXZra0lkTHJucVVOdE9QMDFsd3FoNTVIQWRBXC9FVXRtYXBsZ1ZUelwvWTU2Wjd0eWxDcUdZbWZ4djJaWG1uZExcL0d5QVdzaWNBYVNDT2FnaW1VTWZlUkVMenFqSjZQY3VoeWRLIn0%3D
Quote:He concludes from the available studies that hydroxychloroquine is unlikely to be of dramatic benefit in patients infected with SARS-CoV-2 and certainly has the potential for harm, particularly when administered with azithromycin
and
https://advances.massgeneral.org/research-and-innovation/article-external.aspx?id=1099&utm_medium=email&utm_source=marketo-providers&utm_campaign=FY20-pulmonaryadvances-02may2020&mkt_tok=eyJpIjoiWm1SbVltWTJZMlU0WkRrdyIsInQiOiJQR3VPU1U5QWZrbnkrNk10emtBeDhmTzdcL1FRVlwvMXZra0lkTHJucVVOdE9QMDFsd3FoNTVIQWRBXC9FVXRtYXBsZ1ZUelwvWTU2Wjd0eWxDcUdZbWZ4djJaWG1uZExcL0d5QVdzaWNBYVNDT2FnaW1VTWZlUkVMenFqSjZQY3VoeWRLIn0%3D
Quote:Although earlier anecdotal reports and poorly controlled clinical trials initially raised optimism about the drugs in treating SARS-CoV-2, the authors present mechanistic reasons why these drugs may actually fail. To start, recent studies use data from lab-cultured cells, not patients. This early research also overlooked the powerful immunosuppressive action of the drugs and the fact that they have failed in previous respiratory virus outbreaks, including influenza.
The authors infer that the drugs inhibit innate immune reactions critical to viral defense, as well as the generation of adaptive, cell-mediated immunity that is also necessary to control a virus like SARS-CoV-2.
BC
RE: Chloroquine/hydroxychloroquine and QT - BostonCard - 05-04-2020
The FDA just issued a warning not to use hydroxychloroquine/chloroquine outside of hospitals and/or clinical trials:
https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or
Quote:The FDA is aware of reports of serious heart rhythm problems in patients with COVID-19 treated with hydroxychloroquine or chloroquine, often in combination with azithromycin and other QT prolonging medicines. We are also aware of increased use of these medicines through outpatient prescriptions. Therefore, we would like to remind health care professionals and patients of the known risks associated with both hydroxychloroquine and chloroquine. We will continue to investigate risks associated with the use of hydroxychloroquine and chloroquine for COVID-19 and communicate publicly when we have more information.
Hydroxychloroquine and chloroquine have not been shown to be safe and effective for treating or preventing COVID-19. They are being studied in clinical trials for COVID-19, and we authorized their temporary use during the COVID-19 pandemic for treatment of the virus in hospitalized patients when clinical trials are not available, or participation is not feasible, through an Emergency Use Authorization (EUA). The medicines being used under the hydroxychloroquine/chloroquine EUA are supplied from the Strategic National Stockpile, the national repository of critical medical supplies to be used during public health emergencies. This safety communication reminds physicians and the public of risk information set out in the hydroxychloroquine and chloroquine healthcare provider fact sheets that were required by the EUA.
Hydroxychloroquine and chloroquine can cause abnormal heart rhythms such as QT interval prolongation and a dangerously rapid heart rate called ventricular tachycardia. These risks may increase when these medicines are combined with other medicines known to prolong the QT interval, including the antibiotic azithromycin, which is also being used in some COVID-19 patients without FDA approval for this condition. Patients who also have other health issues such as heart and kidney disease are likely to be at increased risk of these heart problems when receiving these medicines.
BC
RE: Chloroquine/hydroxychloroquine and QT - 2006alum - 05-04-2020
I forget, is the FDA part of the Deep State, or will Faux News finally stop pushing this as a miracle cure? It's unbelievable to me that the precise warning the FDA has just issued has been widely disseminating for well over a month among physicians and yet ignored by our leadership and the talking heads they take their cues from.
RE: Chloroquine/hydroxychloroquine and QT - fullmetal - 05-04-2020
Some dark corners of the right-wing internet have been posting about how Fauci knew about HCQ back in 2015 and that it's his fault that he did not tout HCQ earlier in the pandemic to save lives. These posts are accompanied with sufficiently low-res graphics that quilt together presumed article headlines with appropriate highlighting.
I mean...this is beyond Fox. Maybe OAN? Russia? Ugh.