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Studies (September) - M T - 10-02-2020

We've gotten away from much posting about studies.  Here are a couple of recent reports that caught my eye.

Hidden immune weakness found in 14% of gravely ill COVID-19 patients
Quote:Two papers published online in Science this week ... reveal that in a significant minority of patients with serious COVID-19, the interferon response has been crippled by genetic flaws or by rogue antibodies that attack interferon itself.
..
Another finding, that 94% of the patients with interferon-attacking antibodies were male, also helps explain why men face higher risk of severe disease.
(The article considers the possibility of detecting the genetic flaws to indicate whether one needs to be ultra careful about exposure.
It also considers how the rogue antibodies might be removed.   It does raise the issue that the rogue antibodies might be transferred in convalescent plasma.)

35-year study hints that coronavirus immunity doesn't last long
Quote:In a new study, published Sept. 14 in the journal Nature Medicine, scientists monitored 10 individuals for more than 35 years to determine how often they became infected with the four known seasonal coronaviruses.
"The new data show that immunity to [these 4] coronaviruses tends to be short-lived, with reinfections happening quite often about 12 months later and, in some cases, even sooner,"
(We've been hearing this for some time.  What isn't clear to me still is how infectious those 4 are compared to SARS-COV2 and how often people are exposed.  If people are only exposed once a year to these viruses, this only gives (sorta) an upper bound on immunity.  If people are exposed every week, then it is a tighter bound.)

RE: Studies (September) - Hurlburt88 - 10-03-2020

THanks for posting.  interesting to see the continued learnings.   definitely a long-term battle here!