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Genetic variants and Covid inflammatory reaction - Printable Version

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Genetic variants and Covid inflammatory reaction - akiddoc - 10-17-2020

https://www.medrxiv.org/content/10.1101/2020.09.24.20200048v2

A variety of genetic variants may lead to the abnormal inflammatory reactions in many patients who become very sick.


RE: Genetic variants and Covid inflammatory reaction - BostonCard - 10-17-2020

In addition to the locus on the ABO blood group, these are interesting.  There's a fair bit of work on the effect of interferon pathway mutations and COVID-19.

https://science.sciencemag.org/content/early/2020/09/23/science.abd4585

Some people have auto antibodies against type I interferons, which are associated with life-threatening COVID-19 infections.

https://science.sciencemag.org/content/early/2020/09/29/science.abd4570

Patients with deficiencies in the type I interferon pathways are also more susceptible to severe COVID-19.

Here's a pretty good summary of the two articles:
https://www.sciencemag.org/news/2020/09/hidden-immune-weakness-found-14-gravely-ill-covid-19-patients

BC