04-26-2020, 06:14 PM
One add... there are two main types of serology testing, and they could be used in a complementary fashion to answer the question.
Most of the serology testing that we've seen is an ELISA: ELISA, or enzyme-linked immunosorbent assay, is a screening test used to detect the presence and concentration of specific antibodies that bind to a viral protein. If you need something more specific, then you can do a microneutralization assay which is a highly specific confirmatory test used to measure neutralizing antibodies, or antibodies that can neutralize virus. This method is considered a gold standard for detection of specific antibodies in serum samples. However, compared with the ELISA, the microneutralization assay is labor-intensive and time-consuming, requiring at least 5 days before results are available.
So if you really wanted answers (especially if you are trying to determine whether people can go to work or if you are not sure if your prevalence study is accounted for by false positives) is to screen everyone via ELISA, and then confirm positive tests via the microneutralization assay.
BC
Most of the serology testing that we've seen is an ELISA: ELISA, or enzyme-linked immunosorbent assay, is a screening test used to detect the presence and concentration of specific antibodies that bind to a viral protein. If you need something more specific, then you can do a microneutralization assay which is a highly specific confirmatory test used to measure neutralizing antibodies, or antibodies that can neutralize virus. This method is considered a gold standard for detection of specific antibodies in serum samples. However, compared with the ELISA, the microneutralization assay is labor-intensive and time-consuming, requiring at least 5 days before results are available.
So if you really wanted answers (especially if you are trying to determine whether people can go to work or if you are not sure if your prevalence study is accounted for by false positives) is to screen everyone via ELISA, and then confirm positive tests via the microneutralization assay.
BC