[burger]

The Cell paper is a very interesting one. It shows that Covid19 triggers a normal cellular immune response. This is a good sign for the feasibility of a vaccine, and that there is likely some durable immunity in survivors.

Even more tantalizing to me were their findings that even people who had never been exposed to SARS-COV2 had helper T-cells which could recognize it (50% of their sample actually!). They theorize this could be related to prior non-covid19 coronavirus exposure. If so could explain some of the patients who have a mild or asymptomatic course. This is speculative at this stage but definitely an area for future study. Identifying serology negative people with helper T cells that can still recognize SARS-COV2, and then studying this cohort over time to see if they catch covid19 and what their clinical course is like would be very interesting.

Will need to read more closely and take a look at the other preprint paper which I hadn't seen before.

So, a possible implication is that we should all get colds from coronaviruses besides sars-cov2 to reduce the severity of covid-19.  I'd volunteer for that study.  Hopefully someone is doing this.

The problem with the tracking study of people with possible immunity is that you'd need a truly enormous sample size to catch enough sars-cov2 infections to do any legit analysis.  Regardless, it's an interesting idea.

[burger]

The Cell paper is a very interesting one. It shows that Covid19 triggers a normal cellular immune response. This is a good sign for the feasibility of a vaccine, and that there is likely some durable immunity in survivors.

Even more tantalizing to me were their findings that even people who had never been exposed to SARS-COV2 had helper T-cells which could recognize it (50% of their sample actually!). They theorize this could be related to prior non-covid19 coronavirus exposure. If so could explain some of the patients who have a mild or asymptomatic course. This is speculative at this stage but definitely an area for future study. Identifying serology negative people with helper T cells that can still recognize SARS-COV2, and then studying this cohort over time to see if they catch covid19 and what their clinical course is like would be very interesting.

Will need to read more closely and take a look at the other preprint paper which I hadn't seen before.

So, a possible implication is that we should all get colds from coronaviruses besides sars-cov2 to reduce the severity of covid-19.  I'd volunteer for that study.  Hopefully someone is doing this.

The problem with the tracking study of people with possible immunity is that you'd need a truly enormous sample size to catch enough sars-cov2 infections to do any legit analysis.  Regardless, it's an interesting idea.