[BostonCard]

More concerning:

https://www.nature.com/articles/s41586-020-2538-8

ADE (antibody dependent enhancement), which is what happens with Dengue, is a serious concern.  This is a paradoxical scenario where having antibodies actually makes the infection worse, by enhancing entry of the virus into cells (hence "antibody dependent enhancement")

First, comprehensive studies are urgently needed to define clinical correlates of protective immunity against SARS-CoV-2. Second, since we cannot predict ADE of disease reliably after either vaccination or treatment with antibodies, regardless of what virus is the causative agent, it will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 disease move forward.

BC

[BostonCard]

More concerning:

https://www.nature.com/articles/s41586-020-2538-8

ADE (antibody dependent enhancement), which is what happens with Dengue, is a serious concern.  This is a paradoxical scenario where having antibodies actually makes the infection worse, by enhancing entry of the virus into cells (hence "antibody dependent enhancement")

First, comprehensive studies are urgently needed to define clinical correlates of protective immunity against SARS-CoV-2. Second, since we cannot predict ADE of disease reliably after either vaccination or treatment with antibodies, regardless of what virus is the causative agent, it will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 disease move forward.

BC