[dabigv13]

Not really. Consider the mRNA vaccines, which code only for the spike protein. Any genetic change in the rest of the genome will have no effect. Many genetic changes will not affect the protein structure anyway. And finally, the spike protein is likely to be very stable, since mutations which affect its protein structure would have a good chance of making the virus much less transmissible.

[dabigv13]

Not really. Consider the mRNA vaccines, which code only for the spike protein. Any genetic change in the rest of the genome will have no effect. Many genetic changes will not affect the protein structure anyway. And finally, the spike protein is likely to be very stable, since mutations which affect its protein structure would have a good chance of making the virus much less transmissible.