(03-17-2020, 11:07 PM)akiddoc Wrote: (03-17-2020, 10:45 PM)82 Card Wrote: Careful with the acetaminophen. It's my understanding that acetaminophen reaches toxicity rather quickly if you take more than the recommended dose. You cannot take as many pills as you may be used to if you are a heavy user of ibuprofen.
There are no known interactions between ibuprofen and acetaminophen. They are metabolized differently. Ibuprofen is excreted by the kidneys and has only brief interaction with the liver, while acetaminophen is toxic to the liver in overdose or in those with severe liver disease.
Ibuprofen and Tylenol are often given together for pain or fever control.
I've used them together instead of taking hydrocodone or another opiate. It's a good possibility to know about.
But I think 82 was talking about switching from Ibuprofen to Tylenol, not using them together. If one does that, it's best to beware of the differences.