(03-30-2020, 09:56 AM)OutsiderFan Wrote: Looks like the worst is behind Italy for real now. I'm a bit perplexed how models that a couple weeks ago were showing U.S. peak would be in June, are now being replaced with ones that show peak to be April 15.
I've quoted George Box before, so I will say it again: "All models are wrong, some models are useful". Moreover, because models induce a changes in policy/behaviors, running and publishing the models will change the outcome you are trying to model.
Also, a model that doesn't update as new data comes in is probably useless.
Lastly, all these models have associated prediction intervals. Any result is merely the best guess based on the known parameters. But the parameters (R0, incubation period, etc.) are not known precisely (and can change over time), and small differences in the parameters will have brobdingnagian differences in the outcomes of the models.
The best way to use these things is not as a prediction of the future, but as a bookend for possible scenarios. The far end (worst case) is probably 80% infection rate, 2+% mortality for Covid-19 patients plus spillover effects to patients with other diseases who can't get treatment.
Most likely scenario is the one the President outlined today: 5% of the population gets infected in the acute period and 100,000 - 200,000 dead (1% mortality).
Optimistic scenario is that the measures undertaken slow the pandemic faster and more effectively than we think, and we are looking at 1 million infected and 10,000 dead.
BC
(03-30-2020, 11:05 AM)dabigv13 Wrote: One thing that would result in an earlier peak is social distancing measures. Another is if prevalence is much higher than we expect. Say instead of unmeasured cases being 10x, they are actually 20 or 30x of measured cases. This means its spreading faster than initial models predicted, and so peak will be sooner. Also total deaths lower.
I suspect both of these are true to some extent.
Social distancing usually results in a later peak, not an earlier one, unless social distancing is enough to cause Reff to drop to close to 1 or lower. As Reff comes down from 3 (or 2.5), the curve flattens and is delayed.
You can play around with the effect of social distancing in this online SEIR model:
http://gabgoh.github.io/COVID/index.html
AS R(t) drops from an R0 of 2.2, the peak moves back until you get R(t) gets down to 1.28, and then it starts to move back in.
BC