(10-23-2020, 01:20 PM)BostonCard Wrote: A couple of numbers:
The infectious dose of SARS-CoV (the original SARS virus) is estimated at 300 or so viral particles (this is typically represented as an ID50, or the dose that causes infection in 50% of people) ... The infectious dose of SARS-CoV-2 which causes COVID-19 is probably similar.
Normal talking can generate up to 3000 1-micron particles per minute in exhaled breath,4 and each particle could contain more than 250 virions, which means that a single minute of speaking potentially generates more than 750,000 virions. (link, it is in the second letter). ...
Figuring out how many of those viruses end up being inhaled by the exposed individual is complicated and is affected by a whole host of issues, including mask-wearing, distance, confinement, ventilation, etc.
With these numbers, inhaling one of the 1 micron particles, puts you close to the ID50 dose. Inhale two particles and you're well over that dose. (And, of course, the exhaled particles have a wide spectrum of sizes, and I presume a wide spread of viral particles.) 1 micron particles are well within the aerosol range (typically described as < 5 microns) and in the range to float around in air for a long time.
I believe these numbers are misrepresentative at best. Specifically, I don't see the "3000 1-micron particles per minute in exhaled breath" as stated in the
Brosseau(et al) letter to NEJM. The reference in the letter is to a
study by Asadi. As I understand it, he was looking for aerosolizable particles emitted during vocalizations. I presume the letter authors' "3000 1-micron particles per minute" would come from the paper's slightly less than 50 particles per second. This number is the largest measured value for the loudest continuous "ahhhh" sound (NOT "normal talking"). (I will also note that Asadi indicates that the instrument intentionally did not measure every particle.) If you look at
Figure 5A, you will see that the average loud speech (reading) measured less than 6 particles/second (<360 per minute;). There is a high outlier at 17 particles/second (~ 1000/minute) for someone termed a "speech superemitter".
The letter didn't specify a reference for the 250 virons per micron-sized droplet.
The letter's numbers aside, the Asadi study shows that loud talking (~5.3 particles/sec) results in 75% more particles that intermediate speech (~3.0p/s), and 4x quiet speech(~1.2). Even quiet speech dwarfs mouth breathing (which appears to be ~0.1particles/sec) and nose breathing (too low for me to estimate). Unfortunately, he didn't measure yelling (as in an argument, or at a sporting event).
If anyone is interested, I put together a HTML file (with Javascript) that simulates someone emitting particles at a specified rate in a specified room, with another person inhaling the particles for a specified period, to get a concept of how all these numbers work together to give a dose to the 2nd person.
For example, if you are in a 10'x10'x8' room with an infected person who talks quietly for 15 minutes (1.2 aerosol particles/sec @ 250 virons/particle), with air exchanges at the low end recommended for a household (0.35/hour), and neither has a mask, you will inhale about 580 virons. If the infected person is quiet, you'll get maybe 50 virons.
I don't know about others, but when I've been around people that have drunk too much, they've typically been overly loud. Here's one more reason to avoid anyone in that state. (I would also say that a trip to the library might be one of the safest places to go.;)
From the Asadi article:
Quote:Chao et al. used an interferometric imaging technique to obtain the size distribution of particles larger than 2 μm and found that counting aloud from 1 to 100 releases at least 6 times as many particles as an individual cough. Likewise, Morawska and coworkers reported that counting aloud for 10 seconds followed by 10 seconds of breathing, repeated over two minutes, releases half as many particles as 30 seconds of continual coughing, which in turn releases half as many particles as saying “aah” for 30 seconds.