10-30-2020, 11:03 AM
(This post was last modified: 10-30-2020, 11:30 AM by BostonCard.)
(10-29-2020, 11:45 PM)teejers1 Wrote:(10-29-2020, 04:55 PM)BostonCard Wrote: [tweet]https://twitter.com/axios/status/1321955121761189888?s=20[/tweet]
The 88,000 number is bad, but the real concerning aspect is that hospitals are starting to become strained. Over/under on breaking 100,000 cases by election day?
BC
You know hospital capacity is my bugaboo, so I took interest in your descriptor "starting to become strained" and what that means. Nothing in the link you posted, which I think was just a tweet.
But the Utah reports were bad on that front, as is El Paso. We may see other locales with similar capacity issues, though it's possible we will not. In all events, that should be the driver, and I agree that as you approach real capacity constraints (not theoretical ones), then it's time to pull back/tighten the restrictions.
Meanwhile, SCC remains ridiculously well positioned on the hospital front, as it has throughout all the "surges" and case "explosions."
https://www.sccgov.org/sites/covid19/Pag...x#capacity
(And I say ridiculous because our "Dear Bureaucrat" seems to think those numbers are meaningless).
The good news nationally is that unlike the spring where the pandemic was confined to a small region (New York), now it is widespread and thus less likely to overwhelm one region's healthcare resources. On the other hand, outside of Boston, New York City has one of the highest hospital capacities in the country. Smaller towns and rural areas are less well-covered, and in fact, we've seen a lot of hospitals in rural areas close recently.
BC
(10-29-2020, 07:26 PM)BostonCard Wrote:(10-29-2020, 06:00 PM)lex24 Wrote: Not interested in the prediction game. Good news in Ca. Deaths hit low last week. And the dire prediction on hospitization rates soaring in October did not come to pass.
Course, no one wants to hear good news on this board. Not at least till Biden wins. Which I find interesting - cause I doubt there is one person that reads (or at least posts) on this site that will be voting for Trump. .
Here's some good news:
https://www.fiercebiotech.com/biotech/re...-2-3-trial
Quote:Regeneron’s anti-SARS-CoV-2 antibody cocktail has significantly reduced medical visits in ambulatory COVID-19 patients. The phase 2/3 clinical trial linked REGN-COV2 to a 57% decline in medical visits associated with COVID-19 in the 29 days after treatment.
The downside is that this is an IV antibody cocktail, but you could imagine a case where high risk patients who have been exposed get the cocktail as prophylaxis. Cutting the hospitalization rate by over half is real progress.
BC
And now the bad news.
https://investor.regeneron.com/news-rele...recommends
The independent data safety monitoring board found a potential safety signal in the sicker patients.
Quote:based on a potential safety signal and an unfavorable risk/benefit profile at this time, the IDMC recommends further enrollment of patients requiring high-flow oxygen or mechanical ventilation be placed on hold pending collection and analysis of further data on patients already enrolled.
This is on the back of Eli Lilly stopping its treatment in hospitalized patients.
It looks like if antibody cocktails are going to be used, they would be used for high-risk outpatients, where they reduce the risk of subsequent hospitalization by over 50%. But once patients are already sick enough to require high flow oxygen or be intubated, they run the risk of making patients worse.
Interesting that this was the therapy given to Donald Trump. I'm not sure how sick he was when he got the cocktail, but this is why you generally don't give investigational drugs before they are cleared by the FDA. Imagine if he had a safety event.
BC


